0
1.15
0
15.73
27.59
21.82
18.6
18.98
27.28
26.09
33.91
47.75
54.6
52.32
54.64
100
0
10
100
1000
0 10 100 1000
Gemcitabine[Patient5] (nM)
Afatinib[Patient5] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 10 100 1000
Gemcitabine[Patient5] (nM)
Afatinib[Patient5] (nM)
−20 −10 0 10 20
ZIP synergy score: −0.516
Gemcitabine[Patient5] (nM) & Afatinib[Patient5] (nM)
0
0
12.38
8.01
0
0
9.79
3.58
0
6.51
25.68
29.59
27.59
20.5
21.82
37.38
0
1
10
100
0 0.1 1 10
Gemcitabine[Patient5] (nM)
BI 2536[Patient5] (nM)
0 10 20 30
inhibition (%)
0
1
10
100
0 0.1 1 10
Gemcitabine[Patient5] (nM)
BI 2536[Patient5] (nM)
−20 −10 0 10 20
ZIP synergy score: 3.004
Gemcitabine[Patient5] (nM) & BI 2536[Patient5] (nM)
0
4.03
13.55
76.26
27.59
25.9
49.04
81.31
27.28
35.4
46.57
79.76
54.6
57.59
75.05
100
0
10
100
1000
0 10 100 1000
Gemcitabine[Patient5] (nM)
AZD7762[Patient5] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 10 100 1000
Gemcitabine[Patient5] (nM)
AZD7762[Patient5] (nM)
−30 −20 −10 0 10 20 30
ZIP synergy score: 10.455
Gemcitabine[Patient5] (nM) & AZD7762[Patient5] (nM)
0
0
11.64
16.86
0
0
15.13
22.34
3.57
0
11.41
28.88
99.07
99.07
96.36
95.25
0
1
10
100
0 0.1 1 10
Carfilzomib[Patient5] (nM)
Cabazitaxel[Patient5] (nM)
0 25 50 75
inhibition (%)
0
1
10
100
0 0.1 1 10
Carfilzomib[Patient5] (nM)
Cabazitaxel[Patient5] (nM)
−10 −5 0 5 10
ZIP synergy score: 1.11
Carfilzomib[Patient5] (nM) & Cabazitaxel[Patient5] (nM)
0
0
4.03
13.55
12.38
17.05
16.52
30.1
8.01
15.69
12.53
29.69
54.94
54.22
56.37
69.94
0
1
10
100
0 10 100 1000
BI 2536[Patient5] (nM)
AZD7762[Patient5] (nM)
0 20 40 60
inhibition (%)
0
1
10
100
0 10 100 1000
BI 2536[Patient5] (nM)
AZD7762[Patient5] (nM)
−20 −10 0 10 20
ZIP synergy score: 5.877
BI 2536[Patient5] (nM) & AZD7762[Patient5] (nM)
0
12.38
8.01
54.94
0
16.65
10.99
55.74
22.86
25.53
25.77
63.46
42.49
47.17
48.32
100
0
10
100
1000
0 10 100 1000
Taselisib[Patient5] (nM)
BI 2536[Patient5] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 10 100 1000
Taselisib[Patient5] (nM)
BI 2536[Patient5] (nM)
−10 −5 0 5 10
ZIP synergy score: 1.157
Taselisib[Patient5] (nM) & BI 2536[Patient5] (nM)
0
40.11
99.75
99.91
11.17
44.07
99.93
100
67.76
81.06
100.03
99.84
92.11
98.06
99.84
100
0
100
1000
10000
0 100 1000 10000
Pevonedistat[Patient5] (nM)
Alvocidib[Patient5] (nM)
0 25 50 75 100
inhibition (%)
0
100
1000
10000
0 100 1000 10000
Pevonedistat[Patient5] (nM)
Alvocidib[Patient5] (nM)
−10 −5 0 5 10
ZIP synergy score: 2.111
Pevonedistat[Patient5] (nM) & Alvocidib[Patient5] (nM)
0
1.15
0
15.73
12.38
21.61
13.19
26.89
8.01
10.3
11.21
65.58
54.94
54.68
57.06
100
0
10
100
1000
0 10 100 1000
BI 2536[Patient5] (nM)
Afatinib[Patient5] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 10 100 1000
BI 2536[Patient5] (nM)
Afatinib[Patient5] (nM)
−50 −25 0 25 50
ZIP synergy score: 9.099
BI 2536[Patient5] (nM) & Afatinib[Patient5] (nM)
0
0
0.18
55.2
22.08
19.03
8.63
73.13
26.68
25.77
35.27
78.66
37.91
21.39
10.45
100
0
10
100
1000
0 10 100 1000
Paclitaxel[Patient5] (nM)
Doxorubicin[Patient5] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 10 100 1000
Paclitaxel[Patient5] (nM)
Doxorubicin[Patient5] (nM)
−20 −10 0 10 20
ZIP synergy score: 0.775
Paclitaxel[Patient5] (nM) & Doxorubicin[Patient5] (nM)
0
0
0
13.8
0.88
4.5
1.42
13.67
3.41
10.23
11.11
22.09
57.61
60.48
55.6
100
0
10
100
1000
0 10 100 1000
Talazoparib[Patient5] (nM)
Afatinib[Patient5] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 10 100 1000
Talazoparib[Patient5] (nM)
Afatinib[Patient5] (nM)
−10 −5 0 5 10
ZIP synergy score: 3.054
Talazoparib[Patient5] (nM) & Afatinib[Patient5] (nM)
0
0
0
84.8
5.74
44.84
44.31
87.34
97.22
98.34
97.27
99.03
97.61
98.21
98.66
99.56
0
0.1
1
10
0 10 100 1000
Panobinostat[Patient5] (nM)
Dinaciclib[Patient5] (nM)
0 25 50 75
inhibition (%)
0
0.1
1
10
0 10 100 1000
Panobinostat[Patient5] (nM)
Dinaciclib[Patient5] (nM)
−50 −25 0 25 50
ZIP synergy score: 10.543
Panobinostat[Patient5] (nM) & Dinaciclib[Patient5] (nM)
0
0.88
3.41
57.61
0
0
11.84
63.69
12.06
14.56
22.45
65.98
44.86
36.25
53.03
100
0
10
100
1000
0 10 100 1000
Taselisib[Patient5] (nM)
Talazoparib[Patient5] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 10 100 1000
Taselisib[Patient5] (nM)
Talazoparib[Patient5] (nM)
−10 −5 0 5 10
ZIP synergy score: 3.716
Taselisib[Patient5] (nM) & Talazoparib[Patient5] (nM)
0
5.1
0
24.36
0
1.6
0
12.16
0
0
0
19.12
12.06
16.13
4.12
33.72
0
1
10
100
0 1 10 100
Taselisib[Patient5] (nM)
Pevonedistat[Patient5] (nM)
0 10 20 30
inhibition (%)
0
1
10
100
0 1 10 100
Taselisib[Patient5] (nM)
Pevonedistat[Patient5] (nM)
−10 −5 0 5 10
ZIP synergy score: −2.243
Taselisib[Patient5] (nM) & Pevonedistat[Patient5] (nM)
0
0
0
12.98
5.74
36.13
29.91
49.88
97.22
96.92
96.75
96.99
97.61
96.46
97.53
96.78
0
0.1
1
10
0 10 100 1000
Panobinostat[Patient5] (nM)
AZD7762[Patient5] (nM)
0 25 50 75
inhibition (%)
0
0.1
1
10
0 10 100 1000
Panobinostat[Patient5] (nM)
AZD7762[Patient5] (nM)
−40 −20 0 20 40
ZIP synergy score: 11.085
Panobinostat[Patient5] (nM) & AZD7762[Patient5] (nM)
0
0
0
12.98
0.88
0
12.18
14.26
3.41
21.3
12.01
9.83
57.61
59.25
66.46
69.39
0
0.1
1
10
0 10 100 1000
Talazoparib[Patient5] (nM)
AZD7762[Patient5] (nM)
0 20 40 60
inhibition (%)
0
0.1
1
10
0 10 100 1000
Talazoparib[Patient5] (nM)
AZD7762[Patient5] (nM)
−20 −10 0 10 20
ZIP synergy score: 5.135
Talazoparib[Patient5] (nM) & AZD7762[Patient5] (nM)
0
5.03
0
5.74
5.1
13.38
0
19.36
0
0
0
32.43
24.36
16.73
29.78
31.99
0
0.1
1
10
0 1 10 100
Pevonedistat[Patient5] (nM)
Panobinostat[Patient5] (nM)
0 10 20 30
inhibition (%)
0
0.1
1
10
0 1 10 100
Pevonedistat[Patient5] (nM)
Panobinostat[Patient5] (nM)
−30 −20 −10 0 10 20 30
ZIP synergy score: 5.333
Pevonedistat[Patient5] (nM) & Panobinostat[Patient5] (nM)
0
0
59.56
86.15
19.63
27.19
67.78
88.58
30.13
40.28
73.76
88.49
45.57
65.46
88.18
100
0
10
100
1000
0 10 100 1000
Mubritinib[Patient5] (nM)
Cobimetinib[Patient5] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 10 100 1000
Mubritinib[Patient5] (nM)
Cobimetinib[Patient5] (nM)
−30 −20 −10 0 10 20 30
ZIP synergy score: 7.965
Mubritinib[Patient5] (nM) & Cobimetinib[Patient5] (nM)
0
19.63
30.13
45.57
0.4
17.81
26.9
53.87
3.98
17.39
36.06
57.51
1.64
22.93
36.03
100
0
10
100
1000
0 10 100 1000
Raltitrexed[Patient5] (nM)
Mubritinib[Patient5] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 10 100 1000
Raltitrexed[Patient5] (nM)
Mubritinib[Patient5] (nM)
−20 −10 0 10 20
ZIP synergy score: 4.392
Raltitrexed[Patient5] (nM) & Mubritinib[Patient5] (nM)
0
19.63
30.13
45.57
5.74
51.34
56.07
76.86
97.64
97.53
98.22
98.66
97.4
98.58
99.36
100
0
10
100
1000
0 10 100 1000
Panobinostat[Patient5] (nM)
Mubritinib[Patient5] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 10 100 1000
Panobinostat[Patient5] (nM)
Mubritinib[Patient5] (nM)
−40 −20 0 20 40
ZIP synergy score: 12.847
Panobinostat[Patient5] (nM) & Mubritinib[Patient5] (nM)
0
6.97
10.7
54.56
0
22.07
35.68
68.61
59.56
66.86
75.13
95.15
86.15
87.87
93.71
100
0
10
100
1000
0 10 100 1000
Cobimetinib[Patient5] (nM)
BI 2536[Patient5] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 10 100 1000
Cobimetinib[Patient5] (nM)
BI 2536[Patient5] (nM)
−30 −20 −10 0 10 20 30
ZIP synergy score: 12.198
Cobimetinib[Patient5] (nM) & BI 2536[Patient5] (nM)
0
0.4
3.98
1.64
1.56
0
6.85
2.55
21.46
30.1
22.31
23.12
16.45
19.39
19.76
100
0
10
100
1000
0 1 10 100
Sirolimus[Patient5] (nM)
Raltitrexed[Patient5] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 1 10 100
Sirolimus[Patient5] (nM)
Raltitrexed[Patient5] (nM)
−10 −5 0 5 10
ZIP synergy score: 2.581
Sirolimus[Patient5] (nM) & Raltitrexed[Patient5] (nM)
0
6.97
10.7
54.56
0
17.55
22.6
57.19
0
19.4
19.18
56.4
5.74
58.94
55.37
83.06
0
10
100
1000
0 0.1 1 10
Panobinostat[Patient5] (nM)
BI 2536[Patient5] (nM)
0 20 40 60 80
inhibition (%)
0
10
100
1000
0 0.1 1 10
Panobinostat[Patient5] (nM)
BI 2536[Patient5] (nM)
−50 −25 0 25 50
ZIP synergy score: 18.1
Panobinostat[Patient5] (nM) & BI 2536[Patient5] (nM)
0
6.97
10.7
54.56
0.4
2.53
17.9
61.17
3.98
10.25
25.04
59.66
1.64
16.57
15.39
100
0
10
100
1000
0 10 100 1000
Raltitrexed[Patient5] (nM)
BI 2536[Patient5] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 10 100 1000
Raltitrexed[Patient5] (nM)
BI 2536[Patient5] (nM)
−20 −10 0 10 20
ZIP synergy score: 6.435
Raltitrexed[Patient5] (nM) & BI 2536[Patient5] (nM)
0
0
59.56
86.15
1.56
17.58
61.54
87.87
21.46
43.01
83.09
91.09
16.45
41.42
81.64
100
0
10
100
1000
0 1 10 100
Sirolimus[Patient5] (nM)
Cobimetinib[Patient5] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 1 10 100
Sirolimus[Patient5] (nM)
Cobimetinib[Patient5] (nM)
−30 −20 −10 0 10 20 30
ZIP synergy score: 12.467
Sirolimus[Patient5] (nM) & Cobimetinib[Patient5] (nM)
0
6.1
0.65
3.64
0
0
0
11.62
0
0
0
6.04
24.58
28.28
21.74
33.7
0
1
10
100
0 0.1 1 10
BI 2536[Patient6] (nM)
Afatinib[Patient6] (nM)
0 10 20 30
inhibition (%)
0
1
10
100
0 0.1 1 10
BI 2536[Patient6] (nM)
Afatinib[Patient6] (nM)
−10 −5 0 5 10
ZIP synergy score: 0.375
BI 2536[Patient6] (nM) & Afatinib[Patient6] (nM)
0
0.24
3.69
99.06
80.91
83.38
85.97
97.93
94.24
94.79
95.17
98.15
94.56
96.87
94.24
98.18
0
0.1
1
10
0 10 100 1000
Luminespib[Patient6] (nM)
Bortezomib[Patient6] (nM)
0 25 50 75
inhibition (%)
0
0.1
1
10
0 10 100 1000
Luminespib[Patient6] (nM)
Bortezomib[Patient6] (nM)
−10 −5 0 5 10
ZIP synergy score: 1.297
Luminespib[Patient6] (nM) & Bortezomib[Patient6] (nM)
0
0
0
0
26.87
32.96
29.15
27.83
36.84
48.76
46.49
47.74
90.72
91.48
94.08
93.38
0
1
10
100
0 100 1000 10000
Topotecan[Patient6] (nM)
Doxorubicin[Patient6] (nM)
0 25 50 75
inhibition (%)
0
1
10
100
0 100 1000 10000
Topotecan[Patient6] (nM)
Doxorubicin[Patient6] (nM)
−20 −10 0 10 20
ZIP synergy score: 6.434
Topotecan[Patient6] (nM) & Doxorubicin[Patient6] (nM)
0
0.24
3.69
99.06
0
2.96
0
98.79
0.24
1.87
0.59
98.79
38.09
53.02
54.92
98.98
0
0.1
1
10
0 0.1 1 10
Panobinostat[Patient6] (nM)
Bortezomib[Patient6] (nM)
0 25 50 75
inhibition (%)
0
0.1
1
10
0 0.1 1 10
Panobinostat[Patient6] (nM)
Bortezomib[Patient6] (nM)
−20 −10 0 10 20
ZIP synergy score: 3.645
Panobinostat[Patient6] (nM) & Bortezomib[Patient6] (nM)
0
0
0
0
2.4
2.9
0
0
11.81
26.97
31.55
24.98
58.65
66
60.43
62.83
0
1
10
100
0 0.2 2.5 25
Trametinib[Patient6] (nM)
Doxorubicin[Patient6] (nM)
0 20 40 60
inhibition (%)
0
1
10
100
0 0.2 2.5 25
Trametinib[Patient6] (nM)
Doxorubicin[Patient6] (nM)
−20 −10 0 10 20
ZIP synergy score: 7.06
Trametinib[Patient6] (nM) & Doxorubicin[Patient6] (nM)
0
0
0
0
0
0
0
0
0
0
0
0
6.43
34.76
0
28.76
0
1
10
100
0 0.1 1 10
Paclitaxel[Patient6] (nM)
Doxorubicin[Patient6] (nM)
0 10 20 30
inhibition (%)
0
1
10
100
0 0.1 1 10
Paclitaxel[Patient6] (nM)
Doxorubicin[Patient6] (nM)
−20 −10 0 10 20
ZIP synergy score: 2.787
Paclitaxel[Patient6] (nM) & Doxorubicin[Patient6] (nM)
0
3.33
28.81
39.65
2.4
5.14
44.53
48.6
11.81
22.71
62.42
69.85
58.65
70.49
75.75
76.65
0
1
10
100
0 0.2 2.5 25
Trametinib[Patient6] (nM)
Dasatinib[Patient6] (nM)
0 20 40 60
inhibition (%)
0
1
10
100
0 0.2 2.5 25
Trametinib[Patient6] (nM)
Dasatinib[Patient6] (nM)
−30 −20 −10 0 10 20 30
ZIP synergy score: 13.646
Trametinib[Patient6] (nM) & Dasatinib[Patient6] (nM)
0
0
0
0
0
0
0
49.79
0.24
0
0
83.63
38.09
51.23
47.1
89.05
0
0.1
1
10
0 0.1 1 10
Panobinostat[Patient6] (nM)
Dinaciclib[Patient6] (nM)
0 20 40 60 80
inhibition (%)
0
0.1
1
10
0 0.1 1 10
Panobinostat[Patient6] (nM)
Dinaciclib[Patient6] (nM)
−50 0 50
ZIP synergy score: 19.376
Panobinostat[Patient6] (nM) & Dinaciclib[Patient6] (nM)
0
0
0
83.05
4.29
16.99
26.61
89.44
26.04
21.16
15.07
90.18
64.8
58.31
63.89
91.72
0
0.1
1
10
0 0.2 2.5 25
Trametinib[Patient6] (nM)
Luminespib[Patient6] (nM)
0 25 50 75
inhibition (%)
0
0.1
1
10
0 0.2 2.5 25
Trametinib[Patient6] (nM)
Luminespib[Patient6] (nM)
−20 −10 0 10 20
ZIP synergy score: 4.113
Trametinib[Patient6] (nM) & Luminespib[Patient6] (nM)
0
0
0.28
20.58
0
0
4.67
19.83
0
0
11.71
17.38
42.78
40.03
47.4
56.72
0
10
100
1000
0 1 10 100
Rigosertib[Patient6] (nM)
Afatinib[Patient6] (nM)
0 10 20 30 40 50
inhibition (%)
0
10
100
1000
0 1 10 100
Rigosertib[Patient6] (nM)
Afatinib[Patient6] (nM)
−20 −10 0 10 20
ZIP synergy score: 2.119
Rigosertib[Patient6] (nM) & Afatinib[Patient6] (nM)
0
0
0
42.78
4.29
1.68
2.46
46.42
26.04
30.48
28.14
65.61
64.8
69.46
68.97
83.63
0
1
10
100
0 0.2 2.5 25
Trametinib[Patient6] (nM)
Rigosertib[Patient6] (nM)
0 20 40 60 80
inhibition (%)
0
1
10
100
0 0.2 2.5 25
Trametinib[Patient6] (nM)
Rigosertib[Patient6] (nM)
−10 −5 0 5 10
ZIP synergy score: 3.119
Trametinib[Patient6] (nM) & Rigosertib[Patient6] (nM)
0
0
0
0.28
0
0
10.96
3.79
0
0
8.98
4.45
83.05
85.46
86.18
88.82
0
1
10
100
0 0.1 1 10
Luminespib[Patient6] (nM)
Afatinib[Patient6] (nM)
0 20 40 60 80
inhibition (%)
0
1
10
100
0 0.1 1 10
Luminespib[Patient6] (nM)
Afatinib[Patient6] (nM)
−10 −5 0 5 10
ZIP synergy score: 4.133
Luminespib[Patient6] (nM) & Afatinib[Patient6] (nM)
0
99.41
98.98
98.98
0
98.33
99.6
99.02
23.22
98.59
99.86
99.47
31.89
98.95
99.15
99.8
0
10
100
1000
0 1 10 100
Dasatinib[Patient6] (nM)
Bortezomib[Patient6] (nM)
0 25 50 75
inhibition (%)
0
10
100
1000
0 1 10 100
Dasatinib[Patient6] (nM)
Bortezomib[Patient6] (nM)
−10 −5 0 5 10
ZIP synergy score: 0.013
Dasatinib[Patient6] (nM) & Bortezomib[Patient6] (nM)
0
0
0
0
0
0
0
0
23.22
17.58
28.79
18.92
31.89
36.64
24.03
42.41
0
0.1
1
10
0 1 10 100
Dasatinib[Patient6] (nM)
Afatinib[Patient6] (nM)
0 10 20 30 40
inhibition (%)
0
0.1
1
10
0 1 10 100
Dasatinib[Patient6] (nM)
Afatinib[Patient6] (nM)
−10 −5 0 5 10
ZIP synergy score: −0.466
Dasatinib[Patient6] (nM) & Afatinib[Patient6] (nM)
0
40.62
41.23
44.59
96.77
99.24
98.82
99.15
100.03
98.69
99.37
99.99
100.06
99.8
99.86
100
0
10
100
1000
0 10 100 1000
Carfilzomib[Patient6] (nM)
Cabazitaxel[Patient6] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 10 100 1000
Carfilzomib[Patient6] (nM)
Cabazitaxel[Patient6] (nM)
−10 −5 0 5 10
ZIP synergy score: 0.882
Carfilzomib[Patient6] (nM) & Cabazitaxel[Patient6] (nM)
0
0
23.22
31.89
0
0
24.39
34.07
0
0
25.5
37.72
0
82.4
90.02
88.23
0
1
10
100
0 0.1 1 10
Dinaciclib[Patient6] (nM)
Dasatinib[Patient6] (nM)
0 25 50 75
inhibition (%)
0
1
10
100
0 0.1 1 10
Dinaciclib[Patient6] (nM)
Dasatinib[Patient6] (nM)
−50 0 50
ZIP synergy score: 20.063
Dinaciclib[Patient6] (nM) & Dasatinib[Patient6] (nM)
0
0
0
6.68
32.02
43.86
41.89
46.91
41.73
46.55
39.56
50.92
96.23
92.76
94.33
96.79
0
0.1
1
10
0 100 1000 10000
Tipifarnib[Patient6] (nM)
Mubritinib[Patient6] (nM)
0 25 50 75
inhibition (%)
0
0.1
1
10
0 100 1000 10000
Tipifarnib[Patient6] (nM)
Mubritinib[Patient6] (nM)
−20 −10 0 10 20
ZIP synergy score: 6.595
Tipifarnib[Patient6] (nM) & Mubritinib[Patient6] (nM)
0
7.4
49.05
77.04
32.02
51.15
75.72
83.6
41.73
62.57
87.51
89.08
96.23
98.04
98.53
100
0
10
100
1000
0 100 1000 10000
Tipifarnib[Patient6] (nM)
Cobimetinib[Patient6] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 100 1000 10000
Tipifarnib[Patient6] (nM)
Cobimetinib[Patient6] (nM)
−30 −20 −10 0 10 20 30
ZIP synergy score: 13.501
Tipifarnib[Patient6] (nM) & Cobimetinib[Patient6] (nM)
0
0
14.79
1.84
32.02
30.24
39.89
30.44
41.73
47.24
49.37
43.99
96.23
96.69
97.88
100
0
10
100
1000
0 100 1000 10000
Tipifarnib[Patient6] (nM)
Raltitrexed[Patient6] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 100 1000 10000
Tipifarnib[Patient6] (nM)
Raltitrexed[Patient6] (nM)
−10 −5 0 5 10
ZIP synergy score: 3.267
Tipifarnib[Patient6] (nM) & Raltitrexed[Patient6] (nM)
0
0
4.61
49.34
32.02
31.92
26.07
57.15
41.73
50.46
42.74
72.64
96.23
96.14
96.56
96.99
0
1
10
100
0 100 1000 10000
Tipifarnib[Patient6] (nM)
AZD8055[Patient6] (nM)
0 25 50 75
inhibition (%)
0
1
10
100
0 100 1000 10000
Tipifarnib[Patient6] (nM)
AZD8055[Patient6] (nM)
−10 −5 0 5 10
ZIP synergy score: 1.562
Tipifarnib[Patient6] (nM) & AZD8055[Patient6] (nM)
0
7.4
49.05
77.04
0
5.24
48.65
80.55
14.79
17.94
56.4
84.75
1.84
22.89
51.61
100
0
10
100
1000
0 10 100 1000
Raltitrexed[Patient6] (nM)
Cobimetinib[Patient6] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 10 100 1000
Raltitrexed[Patient6] (nM)
Cobimetinib[Patient6] (nM)
−20 −10 0 10 20
ZIP synergy score: 3.894
Raltitrexed[Patient6] (nM) & Cobimetinib[Patient6] (nM)
0
0
0
6.68
0
0
2.09
16
14.79
3.79
15.02
27.65
1.84
0.25
7.07
22.53
0
0.1
1
10
0 10 100 1000
Raltitrexed[Patient6] (nM)
Mubritinib[Patient6] (nM)
0 10 20
inhibition (%)
0
0.1
1
10
0 10 100 1000
Raltitrexed[Patient6] (nM)
Mubritinib[Patient6] (nM)
−20 −10 0 10 20
ZIP synergy score: 2.466
Raltitrexed[Patient6] (nM) & Mubritinib[Patient6] (nM)
0
49.34
70.14
73.1
0
56.13
71.07
73.07
14.79
56.82
74.64
77.53
1.84
67.23
66.41
100
0
100
1000
10000
0 10 100 1000
Raltitrexed[Patient6] (nM)
AZD8055[Patient6] (nM)
0 25 50 75 100
inhibition (%)
0
100
1000
10000
0 10 100 1000
Raltitrexed[Patient6] (nM)
AZD8055[Patient6] (nM)
−30 −20 −10 0 10 20 30
ZIP synergy score: 6.309
Raltitrexed[Patient6] (nM) & AZD8055[Patient6] (nM)
0
7.4
49.05
77.04
6.68
33.1
55.48
80.88
39.46
47.63
70.21
83.47
61.75
74.31
87.47
100
0
10
100
1000
0 10 100 1000
Mubritinib[Patient6] (nM)
Cobimetinib[Patient6] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 10 100 1000
Mubritinib[Patient6] (nM)
Cobimetinib[Patient6] (nM)
−30 −20 −10 0 10 20 30
ZIP synergy score: 8.77
Mubritinib[Patient6] (nM) & Cobimetinib[Patient6] (nM)
0
0
35.37
98.69
0
0
36.46
100.06
0
8.46
38.28
100.06
36.31
39.2
47.24
99.68
0
100
1000
10000
0 1 10 100
Rigosertib[Patient11] (nM)
Pacritinib[Patient11] (nM)
0 25 50 75 100
inhibition (%)
0
100
1000
10000
0 1 10 100
Rigosertib[Patient11] (nM)
Pacritinib[Patient11] (nM)
−20 −10 0 10 20
ZIP synergy score: 0.819
Rigosertib[Patient11] (nM) & Pacritinib[Patient11] (nM)
0
12.56
17.26
8.08
0
0
21.36
24.17
0
12.94
27.28
28.34
35.37
37.68
39.35
64.62
0
100
1000
10000
0 10 100 1000
Pacritinib[Patient11] (nM)
Danusertib[Patient11] (nM)
0 20 40 60
inhibition (%)
0
100
1000
10000
0 10 100 1000
Pacritinib[Patient11] (nM)
Danusertib[Patient11] (nM)
−30 −20 −10 0 10 20 30
ZIP synergy score: 5.22
Pacritinib[Patient11] (nM) & Danusertib[Patient11] (nM)
0
0
2.31
5.58
0
0
0
0
4.92
2.31
8.92
0
19.73
17.49
19.77
29.56
0
0.1
1
10
0 1 10 100
Topotecan[Patient11] (nM)
Idarubicin[Patient11] (nM)
0 10 20
inhibition (%)
0
0.1
1
10
0 1 10 100
Topotecan[Patient11] (nM)
Idarubicin[Patient11] (nM)
−10 −5 0 5 10
ZIP synergy score: −1.584
Topotecan[Patient11] (nM) & Idarubicin[Patient11] (nM)
0
0
0
0
3.32
0
0
39.12
0
0
0
31.99
8.4
15.37
22.5
44.96
0
0.1
1
10
0 0.1 1 10
Docetaxel[Patient11] (nM)
Dinaciclib[Patient11] (nM)
0 10 20 30 40
inhibition (%)
0
0.1
1
10
0 0.1 1 10
Docetaxel[Patient11] (nM)
Dinaciclib[Patient11] (nM)
−40 −20 0 20 40
ZIP synergy score: 10.8
Docetaxel[Patient11] (nM) & Dinaciclib[Patient11] (nM)
0
0
96.95
99.07
0
31.3
99.45
99.07
0
36.84
99.07
97.17
44.35
35.78
97.48
99.22
0
10
100
1000
0 0.1 1 10
Panobinostat[Patient11] (nM)
Dinaciclib[Patient11] (nM)
0 25 50 75
inhibition (%)
0
10
100
1000
0 0.1 1 10
Panobinostat[Patient11] (nM)
Dinaciclib[Patient11] (nM)
−40 −20 0 20 40
ZIP synergy score: 8.281
Panobinostat[Patient11] (nM) & Dinaciclib[Patient11] (nM)
0
0
9.22
10.78
0
0
17.87
15.44
0
1.48
15.14
21.74
0
45.42
71.14
74.41
0
10
100
1000
0 0.1 1 10
Dinaciclib[Patient11] (nM)
Dactolisib[Patient11] (nM)
0 20 40 60
inhibition (%)
0
10
100
1000
0 0.1 1 10
Dinaciclib[Patient11] (nM)
Dactolisib[Patient11] (nM)
−40 0 40
ZIP synergy score: 17.365
Dinaciclib[Patient11] (nM) & Dactolisib[Patient11] (nM)
0
78.77
86.81
93.08
3.32
85.56
90.12
94.67
0
82
85.26
93
8.4
86.62
90.65
95.73
0
100
1000
10000
0 0.1 1 10
Docetaxel[Patient11] (nM)
Clofarabine[Patient11] (nM)
0 25 50 75
inhibition (%)
0
100
1000
10000
0 0.1 1 10
Docetaxel[Patient11] (nM)
Clofarabine[Patient11] (nM)
−20 −10 0 10 20
ZIP synergy score: 4.358
Docetaxel[Patient11] (nM) & Clofarabine[Patient11] (nM)
0
78.77
86.81
93.08
19.73
80.17
85.33
90.8
20.34
83.74
91.18
95.96
55.44
96.72
98.16
100
0
100
1000
10000
0 100 1000 10000
Topotecan[Patient11] (nM)
Clofarabine[Patient11] (nM)
0 25 50 75 100
inhibition (%)
0
100
1000
10000
0 100 1000 10000
Topotecan[Patient11] (nM)
Clofarabine[Patient11] (nM)
−20 −10 0 10 20
ZIP synergy score: 5.506
Topotecan[Patient11] (nM) & Clofarabine[Patient11] (nM)
0
100.43
100.12
99.36
49.45
100.43
100.43
98.29
49.91
100.43
99.2
100.43
50.22
100.43
100.43
100.43
0
0.1
1
10
0 100 1000 10000
Rigosertib[Patient11] (nM)
Cobimetinib[Patient11] (nM)
0 25 50 75 100
inhibition (%)
0
0.1
1
10
0 100 1000 10000
Rigosertib[Patient11] (nM)
Cobimetinib[Patient11] (nM)
−10 −5 0 5 10
ZIP synergy score: 0.043
Rigosertib[Patient11] (nM) & Cobimetinib[Patient11] (nM)
0
0
0
0
0
0
0
32.17
91.25
100.43
93.69
98.9
86.65
97.37
100.12
100
0
10
100
1000
0 10 100 1000
Carfilzomib[Patient11] (nM)
Cabazitaxel[Patient11] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 10 100 1000
Carfilzomib[Patient11] (nM)
Cabazitaxel[Patient11] (nM)
−40 −20 0 20 40
ZIP synergy score: 9.746
Carfilzomib[Patient11] (nM) & Cabazitaxel[Patient11] (nM)
0
0
0
64.4
0
0
0
69.8
1.82
5.54
0
83.49
14.09
18.4
19.23
78.16
0
0.1
1
10
0 0 0.2 2.5
Trametinib[Patient12] (nM)
Dinaciclib[Patient12] (nM)
0 20 40 60 80
inhibition (%)
0
0.1
1
10
0 0 0.2 2.5
Trametinib[Patient12] (nM)
Dinaciclib[Patient12] (nM)
−20 −10 0 10 20
ZIP synergy score: 4.237
Trametinib[Patient12] (nM) & Dinaciclib[Patient12] (nM)
0
0
0
16.08
0
0
0.66
9.98
1.82
5.42
0.92
25.01
14.09
21.16
12.1
28.29
0
0.1
1
10
0 0 0.2 2.5
Trametinib[Patient12] (nM)
Dactolisib[Patient12] (nM)
0 10 20
inhibition (%)
0
0.1
1
10
0 0 0.2 2.5
Trametinib[Patient12] (nM)
Dactolisib[Patient12] (nM)
−10 −5 0 5 10
ZIP synergy score: 1.546
Trametinib[Patient12] (nM) & Dactolisib[Patient12] (nM)
0
0
36.06
30.05
0
4
37.74
50.27
0
10.11
37.99
44.1
64.4
81.3
72.82
83.75
0
10
100
1000
0 0.1 1 10
Dinaciclib[Patient12] (nM)
AZD8055[Patient12] (nM)
0 20 40 60 80
inhibition (%)
0
10
100
1000
0 0.1 1 10
Dinaciclib[Patient12] (nM)
AZD8055[Patient12] (nM)
−20 −10 0 10 20
ZIP synergy score: 8.195
Dinaciclib[Patient12] (nM) & AZD8055[Patient12] (nM)
0
2.77
0.1
17.62
0
2.14
9.91
35.42
1.82
5.35
8.44
42.88
14.09
25.79
37.42
48.85
0
0.1
1
10
0 0 0.2 2.5
Trametinib[Patient12] (nM)
Panobinostat[Patient12] (nM)
0 10 20 30 40
inhibition (%)
0
0.1
1
10
0 0 0.2 2.5
Trametinib[Patient12] (nM)
Panobinostat[Patient12] (nM)
−30 −20 −10 0 10 20 30
ZIP synergy score: 11.589
Trametinib[Patient12] (nM) & Panobinostat[Patient12] (nM)
0
0
0
93.48
80.08
78.48
81.63
97.88
82.36
81.75
84
99.55
95.38
95.96
92.94
99.49
0
0.1
1
10
0 100 1000 10000
Selinexor[Patient12] (nM)
Bortezomib[Patient12] (nM)
0 25 50 75
inhibition (%)
0
0.1
1
10
0 100 1000 10000
Selinexor[Patient12] (nM)
Bortezomib[Patient12] (nM)
−10 −5 0 5 10
ZIP synergy score: 0.35
Selinexor[Patient12] (nM) & Bortezomib[Patient12] (nM)
0
0
0
59.36
0.1
0
0.47
74.69
17.62
39.67
40.5
92.16
88.63
86.32
87.47
99.17
0
0.1
1
10
0 1 10 100
Panobinostat[Patient12] (nM)
Carfilzomib[Patient12] (nM)
0 25 50 75
inhibition (%)
0
0.1
1
10
0 1 10 100
Panobinostat[Patient12] (nM)
Carfilzomib[Patient12] (nM)
−30 −20 −10 0 10 20 30
ZIP synergy score: 10.565
Panobinostat[Patient12] (nM) & Carfilzomib[Patient12] (nM)
0
0
0
36.06
17.62
43.26
43.65
53.03
88.63
91.26
88.31
92.29
90.56
94.29
94.8
94.29
0
1
10
100
0 10 100 1000
Panobinostat[Patient12] (nM)
AZD8055[Patient12] (nM)
0 25 50 75
inhibition (%)
0
1
10
100
0 10 100 1000
Panobinostat[Patient12] (nM)
AZD8055[Patient12] (nM)
−30 −20 −10 0 10 20 30
ZIP synergy score: 9.853
Panobinostat[Patient12] (nM) & AZD8055[Patient12] (nM)
0
0
0
64.4
0.1
3.87
1.5
65.43
17.62
21.22
41.27
85.67
88.63
89.47
90.62
89.34
0
0.1
1
10
0 1 10 100
Panobinostat[Patient12] (nM)
Dinaciclib[Patient12] (nM)
0 25 50 75
inhibition (%)
0
0.1
1
10
0 1 10 100
Panobinostat[Patient12] (nM)
Dinaciclib[Patient12] (nM)
−30 −20 −10 0 10 20 30
ZIP synergy score: 6.389
Panobinostat[Patient12] (nM) & Dinaciclib[Patient12] (nM)
0
0
1.12
91.63
4.79
19.85
18.3
89.89
11.26
7.71
6.9
91.38
14.75
33.24
20.16
97.79
0
0.1
1
10
0 10 100 1000
Cabazitaxel[Patient12] (nM)
Bortezomib[Patient12] (nM)
0 25 50 75
inhibition (%)
0
0.1
1
10
0 10 100 1000
Cabazitaxel[Patient12] (nM)
Bortezomib[Patient12] (nM)
−20 −10 0 10 20
ZIP synergy score: 5.875
Cabazitaxel[Patient12] (nM) & Bortezomib[Patient12] (nM)
0
0
1.12
91.63
0
1.3
2.8
86.9
0
0
4.79
90.01
0
1.36
6.47
90.76
0
0.1
1
10
0 0.2 2.5 25
Oprozomib[Patient12] (nM)
Bortezomib[Patient12] (nM)
0 25 50 75
inhibition (%)
0
0.1
1
10
0 0.2 2.5 25
Oprozomib[Patient12] (nM)
Bortezomib[Patient12] (nM)
−10 −5 0 5 10
ZIP synergy score: 0.976
Oprozomib[Patient12] (nM) & Bortezomib[Patient12] (nM)
0
4.79
11.26
14.75
0
23.15
25.95
27.2
0
21.47
26.14
27.07
62.56
72.52
83.16
99.41
0
10
100
1000
0 0.1 1 10
Carfilzomib[Patient12] (nM)
Cabazitaxel[Patient12] (nM)
0 25 50 75
inhibition (%)
0
10
100
1000
0 0.1 1 10
Carfilzomib[Patient12] (nM)
Cabazitaxel[Patient12] (nM)
−20 −10 0 10 20
ZIP synergy score: 14.77
Carfilzomib[Patient12] (nM) & Cabazitaxel[Patient12] (nM)
0
3.85
12.01
35.04
4.79
19.48
20.54
38.84
11.26
24.89
22.16
25.77
14.75
15.18
16.49
43.45
0
1
10
100
0 10 100 1000
Cabazitaxel[Patient12] (nM)
AZD8055[Patient12] (nM)
0 10 20 30 40
inhibition (%)
0
1
10
100
0 10 100 1000
Cabazitaxel[Patient12] (nM)
AZD8055[Patient12] (nM)
−20 −10 0 10 20
ZIP synergy score: 3.523
Cabazitaxel[Patient12] (nM) & AZD8055[Patient12] (nM)
0
1
0
2.12
0
0
0
2.61
0
0
0
9.64
0
0
0
13.81
0
10
100
1000
0 0.1 1 10
Idarubicin[Patient12] (nM)
GSK923295[Patient12] (nM)
0 5 10
inhibition (%)
0
10
100
1000
0 0.1 1 10
Idarubicin[Patient12] (nM)
GSK923295[Patient12] (nM)
−10 −5 0 5 10
ZIP synergy score: 0.77
Idarubicin[Patient12] (nM) & GSK923295[Patient12] (nM)
0
0
2.55
7.09
0
0
4.23
10.76
0
0
0.31
0
18.61
23.77
36.85
37.22
0
10
100
1000
0 0.1 1 10
Quisinostat[Patient12] (nM)
Alisertib[Patient12] (nM)
0 10 20 30
inhibition (%)
0
10
100
1000
0 0.1 1 10
Quisinostat[Patient12] (nM)
Alisertib[Patient12] (nM)
−20 −10 0 10 20
ZIP synergy score: 2.417
Quisinostat[Patient12] (nM) & Alisertib[Patient12] (nM)
0
2.55
7.09
36.04
11.32
26.45
37.28
52.66
10.11
20.35
37.78
55.4
25.82
31
38.96
100
0
100
1000
10000
0 2.5 25 250
Trametinib[Patient12] (nM)
Alisertib[Patient12] (nM)
0 25 50 75 100
inhibition (%)
0
100
1000
10000
0 2.5 25 250
Trametinib[Patient12] (nM)
Alisertib[Patient12] (nM)
−30 −20 −10 0 10 20 30
ZIP synergy score: 16.635
Trametinib[Patient12] (nM) & Alisertib[Patient12] (nM)
0
0
2.12
42.45
11.32
16.18
27.38
52.35
10.11
22.72
35.79
50.04
25.82
15.68
36.35
100
0
100
1000
10000
0 2.5 25 250
Trametinib[Patient12] (nM)
GSK923295[Patient12] (nM)
0 25 50 75 100
inhibition (%)
0
100
1000
10000
0 2.5 25 250
Trametinib[Patient12] (nM)
GSK923295[Patient12] (nM)
−30 −20 −10 0 10 20 30
ZIP synergy score: 9.909
Trametinib[Patient12] (nM) & GSK923295[Patient12] (nM)
0
86.19
96.79
99.21
1.73
85.3
98.64
100.11
0
89.32
97.11
99.02
44.63
73.55
81.91
90.91
0
10
100
1000
0 0.1 1 10
Ganetespib[Patient12] (nM)
Bortezomib[Patient12] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 0.1 1 10
Ganetespib[Patient12] (nM)
Bortezomib[Patient12] (nM)
−20 −10 0 10 20
ZIP synergy score: −2.176
Ganetespib[Patient12] (nM) & Bortezomib[Patient12] (nM)
0
1.86
2.62
0
1.73
7.6
15.58
3.32
0
6.26
8.94
8.81
44.63
55.55
64.04
49.29
0
1
10
100
0 0.1 1 10
Ganetespib[Patient12] (nM)
Fulvestrant[Patient12] (nM)
0 20 40 60
inhibition (%)
0
1
10
100
0 0.1 1 10
Ganetespib[Patient12] (nM)
Fulvestrant[Patient12] (nM)
−20 −10 0 10 20
ZIP synergy score: 8.139
Ganetespib[Patient12] (nM) & Fulvestrant[Patient12] (nM)
0
100.33
100.2
100.39
50.02
100.36
100.43
100.36
59.05
100.11
100.36
100.3
60.84
100.43
100.23
100.36
0
10
100
1000
0 10 100 1000
Topotecan[Patient12] (nM)
Etoposide[Patient12] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 10 100 1000
Topotecan[Patient12] (nM)
Etoposide[Patient12] (nM)
−10 −5 0 5 10
ZIP synergy score: 0.179
Topotecan[Patient12] (nM) & Etoposide[Patient12] (nM)
0
0
0
3.2
1.73
0
0
21.45
0
0
5.05
23.5
44.63
49.03
11.88
30.97
0
1
10
100
0 0.1 1 10
Ganetespib[Patient12] (nM)
Cobimetinib[Patient12] (nM)
0 10 20 30 40
inhibition (%)
0
1
10
100
0 0.1 1 10
Ganetespib[Patient12] (nM)
Cobimetinib[Patient12] (nM)
−30 −20 −10 0 10 20 30
ZIP synergy score: 1.612
Ganetespib[Patient12] (nM) & Cobimetinib[Patient12] (nM)
0
0
3.2
27.84
2.62
27.07
26.43
43.86
0
0
31.99
45.39
13.21
25.09
29.82
100
0
10
100
1000
0 10 100 1000
Fulvestrant[Patient12] (nM)
Cobimetinib[Patient12] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 10 100 1000
Fulvestrant[Patient12] (nM)
Cobimetinib[Patient12] (nM)
−30 −20 −10 0 10 20 30
ZIP synergy score: 16.771
Fulvestrant[Patient12] (nM) & Cobimetinib[Patient12] (nM)
0
86.19
96.79
99.21
100.23
100.11
99.72
100.04
100.11
100.36
100.04
99.98
100.23
100.36
100.36
100.43
0
10
100
1000
0 0.1 1 10
Ixabepilone[Patient12] (nM)
Bortezomib[Patient12] (nM)
0 25 50 75 100
inhibition (%)
0
10
100
1000
0 0.1 1 10
Ixabepilone[Patient12] (nM)
Bortezomib[Patient12] (nM)
−10 −5 0 5 10
ZIP synergy score: 0.228
Ixabepilone[Patient12] (nM) & Bortezomib[Patient12] (nM)
